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New Data from Past BACE Inhibitor Trials Shed Light on Side Effects


16 Dec 2020
BACE inhibitors succeeded in stemming the tide of Aβ production in the brain, but the drugs also slightly dulled cognition and shrank the brain, bringing the trials to a screeching halt. Rather than washing their hands of a failure and moving on, researchers continue to dig through the trial data to find out exactly what happened, and perhaps even to chart a way forward for the drugs. Three recent studies all led by Michael Egan at Merck add new insight.
Verubecestat triggered a rapid atrophy that did not get worse.
This happened in amyloid-rich regions, and did not track with neurodegeneration. ....

Northwestern University , United States , University Of Southern California , San Diego , Comunidad Autonoma De Cataluna , Robert Vassar , Jochen Herms , David Scott , Eli Lilly , Eric Mcdade , Robert Sergott , Jessica Shugart , Sant Pau , Paul Aisen , Stefan Lichtenthaler , Eli Lilly Astrazeneca , Alzheimer Network , German Center , Alzheimer Disease Cooperative Study , University Of Melbourne , Washington University In St , Michael Egan , Neurodegenerative Diseases , Cyrille Sur , Clinical Trials , Hospital De Sant Pau ,