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A newly discovered fat “shield” that prevents natural killer cells from being destroyed by their own deadly biological weapons also allows some cancer cells to evade an immune system attack, a study at Columbia University has found.
The findings, which may lead to new treatments for aggressive cancers, were reported Aug. 3 in the journal PLoS Biology by scientists in the Department of Pediatrics at Columbia University Vagelos College of Physicians and Surgeons.
A 3-dimensional model of a natural killer cell (purple) with granules (yellow) attaching to a target cell (gray). A pseudocolor scale shows differences in packing density of lipids on the natural killer cell membrane, with warmer colors indicating higher density. (Orange laboratory)
Lipid blast shield protects natural killer cells and also some cancer cells
A newly discovered fat shield that prevents natural killer cells from being destroyed by their own deadly biological weapons also allows some cancer cells to evade an immune system attack, a study at Columbia University has found.
The findings, which may lead to new treatments for aggressive cancers, were reported August 3 in the journal PLoS Biology by scientists in the Department of Pediatrics at Columbia University Vagelos College of Physicians and Surgeons.
Natural killer cells are prolific assassins
Natural killer cells are our body s first line of defense against pathogens and cancer cells, always present and ready to strike at a moment s notice.