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50 Years Uncovering Synapse Secrets

Untangling the Role of Tau in Alzheimer's Disease

A team has revealed how excess tau impairs signal transmission across synapses in mouse models of Alzheimer s disease, uncovering a potential new drug target for the disease.

Untangling the role of tau in Alzheimer's disease

A study has revealed how tau – a key protein implicated in Alzheimer’s disease – impairs communication between neurons, providing new avenues for trea..

Untangling role of tau in Alzheimer's disease

The uncharted molecular language of the brain

 E-Mail IMAGE: Neurons are like the electrical wiring of our bodies. They are connected by synapses, which play an important role in transferring information. Inside synapses, there are complex molecular machineries, such. view more  Credit: OIST Neurons are like the electrical wiring of our brains, responsible for receiving information from the outside world and conveying this information to the rest of our body. To work correctly, they need to speak to each other, and they do this via synapses - specialized structures that act as junctions between neurons. Synapses not only connect neurons but also receive, process, store, and control all the information that flows within this network. Thus, they are fundamentally important for how we operate. A failure within the synapses can influence our memory, spatial orientation, learning ability, and attention span. This failure is also at the root of many brain diseases, such as Alzheimer s, dementia, autism, ADHD, Parkinso