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Global Initiative to Rapidly Develop a Safe, Globally Accessible and Affordable COVID-19 Antiviral Pill - Technology & Applications | Weizmann Wonder Wander

COVID Moonshot receives key funding to accelerate drug discovery efforts

Developing a Pan-Coronavirus Antiviral Drug for Future Outbreaks

Compound Map provides Foundation for SARS-CoV-2 Inhibitors Discovery

Apr 15 2021 Read 7 Times A new international study(1) has provided a template for how to develop directly-acting antivirals with novel modes of action, that would combat COVID-19 by suppressing the SARS-CoV-2 viral infection. The study focused on the macrodomain part of the Nsp3 gene product that SARS-CoV-2 uses to suppress the host cell’s natural antiviral response. This part of the virus’s machinery, also known as Mac1, is essential for its reproduction: previous studies have shown that viruses that lack it cannot replicate in human cells, suggesting that blocking it with a drug would have the same effect.  The study involved a crystallographic fragment screen of the Nsp3 Mac1 protein by an open science collaboration between researchers from the University of Oxford, the XChem platform at Diamond Light Source, the UK’s national synchrotron and researchers from the QCRG Structural Biology Consortium at the University of California San Francisco.  The international effort

Massive fragment screen points way to new SARS-CoV-2 inhibitors