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New monoclonal antibody vaccine slashes malaria risk in children

A recent study demonstrates that the monoclonal antibody-based vaccine L9LS is safe for children aged 6 to 10 and significantly reduces the risk of malaria infection and clinical symptoms by 70% and 77%, respectively. ....

Kateryna Kon , Subcutaneous Administration , International Council For Harmonisation Good Clinical Practises , Drug Administration , National Institute Of Allergy , World Health Organization , New England Journal , Monoclonal Antibody , Image Credit , International Council , Good Clinical Practises , Malian Food , National Institute , Monoclonal Antibody , Plasmodium Falciparum ,

MIT study reveals circadian impact on drug metabolism in engineered livers

Giving drugs at different times of day could significantly affect how they are metabolized in the liver, according to a new study from MIT. ....

Sangeeta Bhatia , Charles Rice , Institute For Medical Engineering , International Science , Rockefeller University , Koch Institute For Integrative Cancer Research , Us National Cancer Institute , National Institute Of Health , Research Of France , Koch Institute , Technology Initiatives , Dorothy Wilson Professor Of Health Sciences , Massachusetts Institute Of Technology , French National Research Agency , Dorothy Wilson Professor , Health Sciences , Electrical Engineering , Computer Science , Integrative Cancer Research , Medical Engineering , Sandra March , Koch Institute Support , Cancer Institute , National Institute , Medical Research , French National Research ,

Researchers discover protein key to toxoplasmosis pathogen multiplication

Researchers have identified a protein that evolved concurrently with the emergence of cellular compartments crucial for the multiplication of the toxoplasmosis pathogen. ....

Markus Meissner , Elena Jimenez Ruiz , University Of Alberta Canada , Professor Markus Meissner , Experimental Parasitology , Professor Joel Dacks , Birth Defects , Cell Biology , Plasmodium Falciparum ,

New structural insights pave the way for drug-resistant malaria therapies

Structural insights into a potent antimalarial drug candidate's interaction with the malaria parasite Plasmodium falciparum have paved the way for drug-resistant malaria therapies, according to a new study by researchers at Weill Cornell Medicine and Van Andel Institute. ....

Huilin Li , Laura Kirkman , Sanders Tri , Hao Chi Hsu , Van Andel Institute , Rockefeller University , Nature Communications , Institutional Therapeutics Discovery Institute Tri , Memorial Sloan Kettering Cancer Center , World Health Organization , Weill Cornell Medicine , Van Andel , Gang Lin , Weill Cornell , Structural Biology , Enterprise Innovation , Animal Model , Electron Microscopy , Plasmodium Falciparum , Structural Biology ,

Radical cure with primaquine reduces risk of Plasmodium vivax parasitaemia in patients with Plasmodium falciparum infection

1. Patients in the primaquine group reported a significant reduction in parasitemia risk at day 63 compared to those in the standard care group. 2. The majority of adverse events were mild-to-moderate with no treatment-related deaths. Evidence Rating Level: 1 (Excellent) Study Rundown: In areas where Plasmodium vivax and Plasmodium falciparum coexist, there exists an ....

Rating Level , Low Dose Subcutaneous , Intravenous Monoclonal Antibody , Between Aug , Global Health , Plasmodium Falciparum , Plasmodium Vivax , Chronic Disease , Infectious Disease , Public Health ,