the past those kind of vaccine escape variants have not really translated into major global path os gens. we have seen this before, but with the beta variant, with the lambda variant, those never really took off. so there s nothing intrinsic in the spike protein that would account for global spread. the two worst ones, the alpha, that arose out of theuu uk, and the delta variant that rose out of an unvaccinated population in india, was because of amino acid substitution that caused it to be a much more highly transm transmissible. so the most important question for this weekend and next few days, next week is is this variant more transmissible than delta? does it have the ability to