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Exploring how prostate cancer cells resist treatment
December 10, 2020
Research could provide a pathway for prostate cancer therapeutics
Research by a University of Georgia scientist sheds light on how two genes factor into prostate cancer cells becoming resistant to treatment, providing a potential new target for therapeutics.
The two genes, ACSL3 and ACSL4, are from the same family and help cancer cells grow, according to Houjian Cai, associate professor in the College of Pharmacy. He and a team of researchers found that the genes function in an interconnected way, similar to the concept of yin and yang.
Prostate cancer is the second leading cause of cancer deaths among men in the United States, according to the Centers for Disease Control. Castration treatment, the primary therapy used to fight prostate cancer, suppresses the male hormone that helps the cancer grow. With this therapy, expression of the ACSL3 gene typically becomes low, according to Cai. ....

United States , Xiangkun Yang , Yongjie Ma , Michael Bartlett , Junyi Zha , Hanwen Huang , Zachary Lewis , Omar Awad Alsaidan , Zanna Beharry , Houjian Cai , Essilvo Sulejmani , Xiaohan Zhang , Centers For Disease , Us Department Of Defense , National Institutes Of Health , University Of The Virgin , University Of Georgia , Molecular Cancer Research , College Of Pharmacy , National Institutes , ஒன்றுபட்டது மாநிலங்களில் , மைக்கேல் பார்ட்லெட் , சக்கரி லெவிஸ் , மையங்கள் க்கு நோய் , எங்களுக்கு துறை ஆஃப் பாதுகாப்பு , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் ,