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Sperm development linked to testicular cancer

 E-Mail Testicular cancer is the most common type of cancer to affect men between the ages of 15 and 49, and around 95% of these cases are caused by testicular germ cell tumours. Although testicular germ cell tumours typically manifest after puberty, problems in the embryonic development of germ cells can transform them into cancer cells that form tumours later in life. In the embryo, germ cells initially have the potential to form many different cell types, a characteristic called pluripotency. Normally, germ cells lose this ability as embryonic development progresses and they become restricted to only form sex cells - sperm in males and eggs in females - in a process known as sex determination. Male sex determination also coincides with the embryonic period when the cancer cells that form testicular germ cell tumours can develop.

Could intermittent fasting reduce breast cancer risk in obesity?

Could intermittent fasting reduce breast cancer risk in obesity? Written by Jennifer Huizen on February 1, 2021 — Fact checked by Mary Cooke, Ph.D. New research finds that time-restricted feeding improves insulin levels and reduces tumor growth in mice with obesity-driven postmenopausal breast cancer. The study found that tumor growth was driven and accelerated by elevated insulin levels in the mice. It also found that lowering the mice’s insulin levels and improving their metabolic health had an anti-tumor effect. “Time-restricted eating has a positive effect on metabolic health and does not trigger the hunger and irritability that is associated with long-term fasting or calorie restriction,” says Dr. Manasi Das, postdoctoral fellow at the University of California (UC), San Diego and first author.

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When — Not What — Obese Mice Ate Reduced Breast Cancer Risk

When Not What Obese Mice Ate Reduced Breast Cancer Risk Restricting eating to an eight-hour window, when activity is highest, decreased the risk of development, growth and metastasis of breast cancer in mouse models, report researchers at University of California San Diego School of Medicine, Moores Cancer Center and Veterans Affairs San Diego Healthcare System (VASDSH). The findings, published in the January 25, 2021 edition of Nature Communications, show that time-restricted feeding a form of intermittent fasting aligned with circadian rhythms improved metabolic health and tumor circadian rhythms in mice with obesity-driven postmenopausal breast cancer. “Previous research has shown that obesity increases the risk of a variety of cancers by negatively affecting how the body reacts to insulin levels and changing circadian rhythms,” said senior author Nicholas Webster, PhD, professor at UC San Diego School of Medicine and senior research career scientist at VASDSH. “

When -- not what -- obese mice ate reduced breast cancer risk

 E-Mail Restricting eating to an eight-hour window, when activity is highest, decreased the risk of development, growth and metastasis of breast cancer in mouse models, report researchers at University of California San Diego School of Medicine, Moores Cancer Center and Veterans Affairs San Diego Healthcare System (VASDSH). The findings, published in the January 25, 2021 edition of Nature Communications, show that time-restricted feeding a form of intermittent fasting aligned with circadian rhythms improved metabolic health and tumor circadian rhythms in mice with obesity-driven postmenopausal breast cancer. Previous research has shown that obesity increases the risk of a variety of cancers by negatively affecting how the body reacts to insulin levels and changing circadian rhythms, said senior author Nicholas Webster, PhD, professor at UC San Diego School of Medicine and senior research career scientist at VASDSH. We were able to increase insulin sensitivity, reduce hyp