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A link between hypoxia and fetal hemoglobin provides hope for sickle cell disease

Cellular response to low oxygen also increases fetal hemoglobin expression in adults, which could lead to novel treatments for some genetic anemias. ....

Mitchellj Weiss , Ruopeng Feng , Jude Children Research Hospital , Jude Hematology Department , Jude Children , Research Hospital , Sickle Cell , Fetal Hemoglobin ,

Link between hypoxia and fetal hemoglobin provides hope for sickle cell disease

Link between hypoxia and fetal hemoglobin provides hope for sickle cell disease
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United States , University Of Pennsylvania , Peng Xu , Yong Cheng , Lance Palmer , Peng Huang , Kalin Mayberry , Ruopeng Feng , Mitchellj Weiss , Thiyagaraj Mayuranathan , M Celeste Simon , Chunliang Li , Gerda Blobel , Phillipa Doerfler , Yu Yao , Jingjing Zhang , Yichao Li , Georgios Christakopoulos , National Institute Of Diabetes , Jude Children Research Hospital , National Institutes Of Health , Jude Hematology Department , Jude Collaborative Research Consortium , Cooley Anemia Foundation Postdoctoral Research Award , Assisi Foundation Of Memphis , Jude Hematology ,

Scientists show how cellular hypoxia response increases fetal hemoglobin expression in adults

Scientists at St. Jude Children's Research Hospital have shown how a protein responsible for adapting to low oxygen conditions (hypoxia), causes increased expression of fetal hemoglobin (HbF) in adults. ....

United States , University Of Pennsylvania , Peng Xu , Yong Cheng , Lance Palmer , Peng Huang , Kalin Mayberry , Emily Henderson , Ruopeng Feng , Mitchellj Weiss , Thiyagaraj Mayuranathan , M Celeste Simon , Chunliang Li , Gerda Blobel , Phillipa Doerfler , Yu Yao , Jingjing Zhang , Yichao Li , Georgios Christakopoulos , National Institute Of Diabetes , Jude Children Research Hospital , National Institutes Of Health , Jude Hematology Department , Jude Collaborative Research Consortium , Cooley Anemia Foundation Postdoctoral Research Award , Assisi Foundation Of Memphis ,

Obscure protein is spotlighted in fight against leukemia

Acute myeloid leukemia (AML) is an aggressive cancer of white blood cells with few effective targeted therapies available to treat it. Cold Spring ....

Osamae Demerdash , Seema Irani , Zhaolin Yang , Lukasa Benjamin , Sofya Polyanskaya , Yan Jessie Zhang , Christopherr Vakoc , Rosamariay Moreno , Ruopeng Feng , Mitchellj Weiss , Olaf Klingbeil , Yu Yao , Christopher Vakoc , Sofyaa Polyanskaya , Yiliang Wei , Cold Spring Harbor Laboratory , Spring Harbor Laboratory , Professor Christopher Vakoc ,