An open-letter of complaint to the Director-General of the World Health Organization, Dr. Margaret Chan chanm@who.int Cc: The Ministry of Health, Labour and Welfare, Japan, www-admin@nhlw.go.jp Minister of Health, Labour and Welfare, Japan, shiozaki@y-shiozaki.or.jp Thomas Frieden, Director CDC, tomfrieden@cdc.gov Vice-Chancellor, Professor Stuart McCutcheon, The University of Auckland, s.mccutcheon@auckland,ac.nz From: Sin…
New-zealand
Japan
Kanbe
Japan-general
Belfast
United-kingdom
Tokyo
United-states
Auckland
Japanese
Brouckaertp-caspase
Melinda-wharton
Molecular Diagnostics Lab in Milford, Connecticut Announces SARS CoV-2 Detection Test Including Variants
This routine DNA sequence electropherogram covering the ACE2 receptor binding domain shows 7 vertical black bars from left to right, pointing to 7 key nucleotides identified as A, G, T, G, A, T and A in the S gene of SARS-CoV-2 in a nasopharyngeal swab specimen taken from a patient with acute respiratory infection. The nucleotide A pointed by the 5th bar is a mutated base, indicating an E484K amino acid mutation (G>A nucleotide mutation). All other 6 black bars point to wildtype bases, confirming the lack of K417N, K417T, L452R, S477N, E484Q, S494P and N501Y mutations in this virus isolate. All known newly emerging SARS-CoV-2 variants of concern are associated with at least one of the 8 amino acid mutations identified in this sequence. Specimens harboring any of these 8 amino acid mutations will be further sequenced for A67V, Δ69/70, T95I, Δ144Y, Y145del, H146del, W152C and V11
India
Connecticut
United-states
Chan-lee
Connecticut-department-of-public-health
Milford-molecular-diagnostics-laboratory
Sin-hang-lee
Milford-molecular-diagnostics
Business-wire
Sin-han-lee
Milford-connecticut
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