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The excluded school children with nowhere to go

Excluded children in a third of areas are stuck on waiting lists for provision, as exclusions appear to be rising faster than councils can keep up with ....

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HMS Spey, first Royal Navy to visit Pitcairn Islands since New Year's eve 2018

Royal Navy sailors delivered Covid vaccines to the descendants of the Bounty when patrol ship HMS Spey visited the tiny Pitcairn Islands in the Pacific. The islands – which are in the middle of the South Pacific and home to only around 50 people – are one of Britain’s most isolated Overseas Territories, famous as the last resting place of HMS Bounty and its mutineers. ....

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New humanized mouse model provides insight into immunotherapy resistance

Credit: The Wistar Institute
PHILADELPHIA (Jan. 12, 2021) Scientists at The Wistar Institute have created an advanced humanized immune system mouse model that allows them to examine resistance to immune checkpoint blockade therapies in melanoma. It has revealed a central role for mast cells. These findings were published today in the journal
Nature Communications.
Checkpoint inhibitors revolutionized therapeutic options for advanced melanoma. However, only a fraction of patients respond to this treatment and some relapse due to reemergence of therapy-resistant lesions.
To better understand why some cancers do not respond or become resistant to checkpoint therapies, we need more preclinical models that mimic the human tumor immune environment, said Rajasekharan Somasundaram, Ph.D., a member of The Wistar Institute Melanoma Research Center, who is the first and corresponding author of the paper. ....

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