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Tisagenlecleucel Yields Durable Responses in R/R Follicular Lymphoma

Patients with relapsed/refractory follicular lymphoma experienced durable responses when treated with tisagenlecleucel (Kymriah) in the phase 2 ELARA study (NCT03568461), according to data presented at the 2023 ASH Annual Meeting.

Stephenj-schuster
Margarita-louis-dreyfus-professor
Chronic-lymphocytic-leukemia
Lymphoma-clinical-care
Cash
Tisagenlecleucel
Follicular-lymphoma
Elara-study
Relapsed-refractory-follicular-lymphoma
Kymriah

Five years later: CAR T therapy shows long-lasting remissions in non-Hodgkin lymphomas

Five years later: CAR T therapy shows long-lasting remissions in non-Hodgkin lymphomas Findings represent the longest follow-up data to date for a personalized cellular therapy approved by the FDA for the treatment of aggressive lymphomas. A significant number of non-Hodgkin lymphoma (NHL) patients in a Penn Medicine-initiated clinical trial continue to be in remission five years after receiving the chimeric antigen receptor (CAR) T cell therapy Kymriah™, researchers in Penn’s Abramson Cancer Center reported in the Medicine. The findings represent the longest follow-up, published data to date for CAR T cell therapies approved by the U.S. Food and Drug Administration for the treatment of relapsed or refractory large B-cell lymphomas.

Stephenj-schuster
Marco-ruella
Elisea-chong
Penn-abramson-cancer-center
Penn-perelman-school-of-medicine
Research-in-penn-perelman-school-of-medicine
Lymphoma-program
Drug-administration
Perelman-school-of-medicine
Abramson-cancer-center
Penn-medicine-initiated
New-england-journal

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