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The first comprehensive analysis of the global impact of AMR, published in The Lancet, estimates it caused 1.27 million deaths in 2019, and antimicrobial-resistant infections played a role in 4.95 million deaths. Estimates for 204 countries and territories confirm AMR as a global health threat, with worst impacts in low- and middle-income countries (LMICs), though higher income countries also face alarmingly high levels of AMR.