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Augmented drug preferentially eliminates cancer cells but does not harm healthy cells

Johns Hopkins Medicine researchers have revamped an anti-cancer drug to better target cancer cells and leave healthy tissues unharmed. Scientists have dubbed this type of targeted approach a "prodrug" -; a medicine designed to release its payload in a particular area of the body and in no other areas. ....

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'Prodrug' targets cancer cell appetite for glutamine, leaves healthy cells unharmed

'Prodrug' targets cancer cell appetite for glutamine, leaves healthy cells unharmed
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Johns Hopkins Researchers Design 'Prodrug' That Targets Cancer Cells' Big Appetite for Glutamine, Leaving Healthy Cells Unharmed

Johns Hopkins Researchers Design 'Prodrug' That Targets Cancer Cells' Big Appetite for Glutamine, Leaving Healthy Cells Unharmed
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Molecular biologist Andrew Holland receives President's Frontier Award

Molecular biologist Andrew Holland receives President s Frontier Award
The $250,000 Johns Hopkins award recognizes scholars who are on the cusp of becoming leaders in their fields
By
Saralyn Cruickshank
/
Published
Feb 15, 2021
Cell division is the fundamental process for life. But when it goes awry, life itself can be threatened.
The fragile balance of centrosomes within animal cells and the cellular functions these organelles control are essential to a form of cell division called mitosis. That s where molecular biologist Andrew Holland focuses his research.
We ve been trying to understand if there are differences in the way healthy cells and tumor cells divide, and if we can exploit those differences in therapies to selectively destroy dividing tumor cells and spare the healthy cells, said Holland, an associate professor in the Department of Molecular Biology and Genetics and the Department of Oncol ....

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