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SARS-CoV-2 suppresses host innate immunity


SARS-CoV-2 suppresses host innate immunity
SARS-CoV-2, the virus that causes COVID-19, blocks the processes of innate immune activation that normally direct the production and/or signaling of type I interferon (IFN-I) by the infected cell and tissues. IFN-I is a key component of host innate immunity that is responsible for eliminating the virus at the early stage of infection, as summarized in a recent review article in
Journal of Interferon & Cytokine Research (JICR). By suppressing innate immunity, the virus replicates and spreads in the body unchecked, leading to the disease known as COVID-19.
SARS-CoV-2 utilizes various approaches to evade host IFN-I response, including suppression of IFN-I production and IFN-I signaling. Viruses defective in antagonizing IFN-I response, in combination with replication-defective mutations, could potentially be developed as live attenuated vaccine candidates. ....

Benjamin Liu , Pei Yong Shi , Harry Hill , Ricardo Pereda , Hongjie Xia , Emily Henderson , Journal Of Interferon Cytokine Research , University Of Texas Medical Branch At Galveston , University Of Washington , Department Of Immunology , Cytokine Research , Texas Medical Branch , Innate Immunity , Immune Disease , Genetic Engineering , Sars Cov 2 , பெஞ்சமின் லியூ , பேய் யோங் ஷி , ஹாரி மலை , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் மருத்துவ கிளை இல் கால்வெஸ்டன் , பல்கலைக்கழகம் ஆஃப் வாஷிங்டன் , துறை ஆஃப் நோயெதிர்ப்பு , டெக்சாஸ் மருத்துவ கிளை , உள்ளார்ந்த நோய் எதிர்ப்பு சக்தி , நோய் எதிர்ப்பு சக்தி நோய் ,