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Two hours. [background noises] [background noises] good morning the Senate Special committee will come to order welcome everybody. Welcome to the committees eighth hearing of the one her 18th congress about Drug Development for rare and serious diseases. As is the tradition of the committee, the aging Committee Ranking member, Ranking Member brought in this case will offer an opening statement. Thank you, senator. Thank the witnesses for coming and for all of the folks from around the country here today. There are over 7000 rare progressive and serious diseases known to man. It is estimated 95 black treatment. Yet in my time et cetera there is not been one Senate Hearing to examine promising therapies for ....