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Research News - Success in Reversing Dementia in Mice Sets the Stage for Human Clinical Trials


Research News
Research News
2021-06-29
Researchers have identified a new treatment candidate that appears to not only halt neurodegenerative symptoms in mouse models of dementia and Alzheimer s disease, but also reverse the effects of the disorders.
The team, based at Tohoku University, published their results on June 8 in the International Journal of Molecular Sciences. The treatment candidate has been declared safe by Japan s governing board, and the researchers plan to begin clinical trials in humans in the next year.
There are currently no disease-modifying therapeutics for neurodegenerative disorders such as Alzheimer s disease, Lewy body dementia, Huntington disease and frontotemporal dementia in the world, said paper author Kohji Fukunaga, professor emeritus in Tohoku University s Graduate School of Pharmaceutical Sciences. We discovered the novel, disease-modifying therapeutic candidate SAK3, which, in our studies, rescued neurons in most protein-mis ....

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