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Impaired drainage also may play a role in Alzheimer’s in people
The drainage network in a mouse’s brain is outlined in blue and green, and dotted with clumps of the Alzheimer’s protein amyloid beta (red). Researchers at Washington University School of Medicine in St. Louis have found that improving the function of the network, known as the meningeal lymphatics, can make certain experimental Alzheimer’s therapies more effective in mice. (Image: Sandro Da Mesquita)
April 28, 2021 SHARE
Experimental Alzheimer’s drugs have shown little success in slowing declines in memory and thinking, leaving scientists searching for explanations. But new research in mice has shown that some investigational Alzheimer’s therapies are more effective when paired with a treatment geared toward improving drainage of fluid and debris from the brain, according to a study led by researchers at Washington University School of Medicine in St. Louis.
The drainage network in a mouse s brain is outlined in blue and green, and dotted with clumps of the Alzheimer s protein amyloid beta (red). Researchers at Washington University School of Medicine in St. Louis have found that improving the function of the network, known as the meningeal lymphatics, can make certain experimental Alzheimer s therapies more effective in mice. Credit: Sandro Da Mesquita Read Time:
Experimental Alzheimer s drugs have shown little success in slowing declines in memory and thinking, leaving scientists searching for explanations. But new research in mice has shown that some investigational Alzheimer s therapies are more effective when paired with a treatment geared toward improving drainage of fluid and debris from the brain, according to a study led by researchers at Washington University School of Medicine in St. Louis.
Repairing faulty drains could be key to unlocking the potential of Alzheimer s therapies
Experimental Alzheimer s drugs have shown little success in slowing declines in memory and thinking, leaving scientists searching for explanations.
But new research in mice has shown that some investigational Alzheimer s therapies are more effective when paired with a treatment geared toward improving drainage of fluid -; and debris -; from the brain, according to a study led by researchers at Washington University School of Medicine in St. Louis.
The findings, published April 28 in the journal Nature, suggest that the brain s drainage system -; known as the meningeal lymphatics -; plays a pivotal but underappreciated role in neurodegenerative disease, and that repairing faulty drains could be a key to unlocking the potential of certain Alzheimer s therapies.
Date Time
Draining brain’s debris enhances Alzheimer’s therapies in mice
Experimental Alzheimer’s drugs have shown little success in slowing declines in memory and thinking, leaving scientists searching for explanations. But new research in mice has shown that some investigational Alzheimer’s therapies are more effective when paired with a treatment geared toward improving drainage of fluid – and debris – from the brain, according to a study led by researchers at Washington University School of Medicine in St. Louis.
The findings, published April 28 in the journal Nature, suggest that the brain’s drainage system – known as the meningeal lymphatics – plays a pivotal but underappreciated role in neurodegenerative disease, and that repairing faulty drains could be a key to unlocking the potential of certain Alzheimer’s therapies.