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Evidence for Efficacy of Antidepressants for Pain Is Limited

In 11 comparisons, antidepressants were efficacious, but they were inefficacious or evidence was inconclusive for 31 comparisons.

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Antidepressants Mostly Ineffective, 'Lackluster' for Chronic Pain

In a new analysis of 26 systematic reviews, most comparisons had inconclusive evidence of the effectiveness of antidepressants compared with placebo in treating pain.

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