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First Arab Middle Eastern Genetics Research In Autism Goes Global

First Arab Middle Eastern Genetics Research In Autism Goes Global
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Stephen Scherer , Madeeha Kamal , Khalid Fakhro , Qatar Foundation , Sidra Medicine , World Autism Awareness Day , Autism Spectrum Disorder , Genome Medicine , Middle Eastern , Sick Children , Autism Speak , Genome Sequencing Project , Autism Speaks ,

PQG Seminar Series


Integrative Approaches to Identifying Function and Significance of Adiposity Susceptibility Genes
In 2019, ~100 million Americans were obese, fueling increases in obesity-related morbidity, mortality, and health care costs, largely from cardiometabolic diseases (CMD). GWAS have demonstrated the fundamental role of genetic susceptibility in obesity risk, including the >1000 loci identified to date. Each GWAS-identified locus potentially provides novel biologic insight; yet the identification of the functional variants, genes, and underlying pathways at these loci has limited translation for precision medicine. OMICs (e.g. genetics, transcriptOMICs, methylOMICs, and metabolOMICs) lie along pathways linking genetic susceptibility to obesity and are emerging as powerful disease biomarkers that provide targetable “mechanistic bridges” linking GWAS findings with obesity risk.  OMIC scans in the same individuals in which obesity associated loci discoveries were made are now avai ....

Israel General , United States , Hebrew University , Karen Conneely , Shai Carmi , Amanda King , Tamar Sofer Cheng Zhong Zhang , Hailiang Huang , Chunyu Liu , Karen Miga , Gillings School Of Public Health , Emory University School Of Medicine , Department Of Human Genetics , Genome Sciences , Hebrew University Of Jerusalem , Dana Farber Cancer Institute , Harvard Medical School , Bu School Of Public Health , Carolina Center , Research Associate Professor , Transomics For Precision Medicine Topmed Program , Community Medicine , Research In Genomic Epidemiology , Behavioral Sciences , Braun School Of Public Health , Itamar Sofer ,