Liberty, meanwhile, occupy eleventh position.
The major talking point of Kotoko s team news was the presence of new Brazilian signing Fabio Gama Dos Santos for his first start for his new club.
Joining the former Brazil U17 and U21 attacker in coach Johnson Smith s starting line-up were Mubarik Yusif, Samuel Frimpong and Emmanuel Sarkodie, with Habib Mohammed and Emmanuel Gyamfi among the casualties.
Kotoko went all guns blazing from the start as Opoku set up Christopher Nettey for a first goalscoring opportunity in the second minute but the defender s final effort went wide.
In the 10th minute, the Porcupine Warriors broke the deadlock as Opoku latched on to a Gama ball inside the box, created space for himself before shooting into the net to make it 1-0.
Visiting coach Johnson Smith handed young midfielder Emmanuel Sarkodie a starting opportunity to debut for the club while also bringing Samuel Frimpong, Abdul Ganiyu and Habib Mohammed into the starting line-up
Medeama coach Samuel Boadu handed attacking responsibilities to Kwasi Donsu, Kwadwo Asamoah, Rashid Nortey and Eric Kwakwa in his set-up.
Before the match could witness any clear scoring chance, the home side were forced into an early substitution as Ali Ouattara went down injured and had to be replaced by Baba Musah in the 12th minute.
In the 16th minute, Kwakwa s shot from outside the box went off target, moments before Kotoko goalkeeper Razak Abalora denied Patrick Yeboah the opener.
Abbas Mohammed climbs off bench to score for Medeama in Asante Kotoko draw ghanafa.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from ghanafa.org Daily Mail and Mail on Sunday newspapers.