Individuals with hybrid immunity had the highest magnitude and durability of protection, and may be able to extend the period before booster vaccinations are needed compared to individuals who have never been infected, according to a new study. Hybrid immunity refers to immunity developed through a combination of SARS-CoV-2 infection and vaccination.
All estimates of protection waned within months against reinfection but remained high
and sustained for hospital admission or severe disease. Individuals with hybrid immunity
had the highest magnitude and durability of protection, and as a result might be able
to extend the period before booster vaccinations are needed compared to individuals
who have never been infected.
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