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Essential Mechanisms Identified for Proper Skin Development


Essential Mechanisms Identified for Proper Skin Development
A severely burned left hand with permanent scars against a plain background
February 22, 2021
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An international research team reports that it has found that Polycomb complexes are essential for proper skin development. This latest discovery could improve development of future stem cell therapies to generate “skin on a dish” to transplant into burn victims and patients with skin-blistering disorders, according to the scientists, who published their study “Polycomb complexes redundantly maintain epidermal stem cell identity during development” in
Genes & Development.
“Polycomb repressive complex 1 (PRC1) and PRC2 are critical epigenetic developmental regulators. PRC1 and PRC2 largely overlap in their genomic binding and cooperate to establish repressive chromatin domains demarcated by H2AK119ub and H3K27me3. However, the functional contribution of each complex to gene repression has ....

New York , United States , Elena Ezhkova , Icahn School Of Medicine At Mount Sinai , Genes Development , Family Stem Cell Institute , Black Family Stem Cell Institute , Icahn School , Mount Sinai , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , இக்ஹ்ன் பள்ளி ஆஃப் மருந்து இல் ஏற்ற சினை , ஜீந்ஸ் வளர்ச்சி , குடும்பம் தண்டு செல் நிறுவனம் , கருப்பு குடும்பம் தண்டு செல் நிறுவனம் , இக்ஹ்ன் பள்ளி , ஏற்ற சினை ,