Since 2019, the UK’s strong reputation in global health has been undermined by a series of deep cuts and a distracting departmental reorganisation. 2024 may, however, represent a turning point, with new Foreign and Development Ministers, both with a strong track record on development, the implementation of a new development white paper, and an election which brings a new government with new priorities. In this paper, we summarise the challenges and opportunities in global health on which the UK will need to act if it wishes to restore its reputation.