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Grow the skin you're in: In vivo generation of chimeric skin grafts

Researchers found that mutated mouse embryos showing an abnormal epidermal differentiation and injected with mouse pluripotent stem cells grew large patches of mature epidermis derived from the donor cells that survived transplantation to adult mice and grew natural-looking fur. Injecting the embryos with human keratinoctyes produced sheets of semi-humanized skin, suggesting that this system could be developed further to grow autologous skin grafts for treating severe skin wounds.

Researchers develop novel method to 'grow your own' donor skin

Skin grafting is an essential procedure used to treat severe skin wounds. In the case of extensive wounds, however, it can be challenging to harvest enough donor skin, and generating artificial skin substitutes that include hair follicles and sweat glands and can engraft on deep wounds has not been successful.

New Technique Enables In Vivo Generation of Skin Grafts

Grow the skin you're in: In vivo generation of chimeric skin grafts

Researchers from Tokyo Medical and Dental University (TMDU) have found that donor keratinocytes injected into mouse embryos form sheets of epidermis that can be used as autologous skin grafts.

Grow the skin you're in: in vivo generation o