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IMAGE: The experimental drug avasopasem manganese protects healthy tissue while enhancing radiation s capacity to kill cancerous tumor cells by converting superoxide to hydrogen peroxide.
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Credit: Michael Story, Ph.D.
DALLAS - May 20, 2021 - An experimental drug that has shown promise in protecting healthy tissue from collateral damage caused by radiation therapy for cancer also appears to enhance radiation s capacity to kill tumors, a new study led by UT Southwestern scientists shows. The findings, published online in
Science Translational Medicine, could provide a much-needed boost to the radiation treatments used against a variety of tumor types.
The drug, avasopasem manganese (AVA), has already shown promise in clinical trials to prevent a side effect known as acute mucositis. This condition commonly occurs in head and neck cancer patients when radiation therapy damages mucous membranes. However, for this drug to become part o ....

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