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Psoriasis Therapeutic Could Tweak an Alternate Target in a Trio

Mice having a keratinocyte-specific deletion of the receptor for the cytokine TWEAK, Fn14, display reduced skin inflammation upon chemical induction, including decreased epidermal hyperplasia and less expression of psoriasis signature genes. Based on this finding and transcriptomic analysis of human keratinocytes, Michael Croft, PhD, and his team have shown TWEAK works together with the known cytokines TNF or IL-17 in provoking inflammation in psoriasis. The study shows targeting TWEAK could offer an alternative approach to treating the disease. ....

Michael Croft , Rinkesh Gupta , Croft Lab , Jolla Institute For Immunology , Us National Institutes Of Health , Science Immunology ,

A trio of proteins found to drive inflammation in psoriasis

About 7.5 million Americans suffer from psoriasis, an autoimmune disease that shows up as patches of red, inflamed skin and painful, scaly rashes. Although there are effective treatments for psoriasis, not everyone responds to these therapies-;and for many, the relief is temporary. ....

United States , Michael Croft , Rinkesh Gupta , Emily Henderson , Croft Lab , Jolla Institute For Immunology , Science Immunology , Atopic Dermatitis , Autoimmune Disease , Skin Cells ,

Suffering from psoriasis? Blame this trio of proteins

Suffering from psoriasis? Blame this trio of proteins
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United States , Kai Fung , Michael Croft , Daniela Salgado Figueroa , Rinkesh Gupta , Haruka Miki , Linda Burkly , Jacqueline Miller , Croft Lab , Jolla Institute For Immunology , National Institutes Of Health , Professor Michael Croft , Science Immunology , National Institutes ,