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Immune Cells in Cerebrospinal Fluid Predict Response of Brain Metastasis to Immunotherapy

Immune Cells in Cerebrospinal Fluid Predict Response of Brain Metastasis to Immunotherapy
March 9, 2021
Studies by researchers at the Vall d’Hebron Institute of Oncology (VHIO), and the National Centre for Genomic Analysis-Centre for Genomic Regulation (CNAG-CRG), Barcelona, have demonstrated how immune cells that access the cerebrospinal fluid (CSF) of patients with brain metastases faithfully recapitulate the characteristics of the brain tumor immune cells, and could represent novel biomarkers of response to immune checkpoint inhibitor (ICI) therapy.
The team used single-cell RNA sequencing combined with T cell receptor genotyping to characterize immune cells in brain lesions and matched CSF. The single-cell profiling allowed them to chart the major cell types and transient tumor-sepcific states in the brain metastasis (BrM) tumor microenvironment (TME). Describing their results in ....

Israel General , Comunidad Autonoma De Cataluna , Joan Seoane , Holger Heyn , Single Cell Genomics Team , Nature Communications , National Centre For Genomic Analysis , Hebron Institute Of Oncology , Centre For Genomic Regulation , Hebron University Hospital , Translational Research , Hebron Institute , National Centre , Genomic Analysis Centre , Genomic Regulation , Cell Genomics Team , இஸ்ரேல் ஜநரல் , காமுனிடட தன்னாட்சி டி கடலுள் , ஜோன் சேஓநெ , ஒற்றை செல் மரபியல் அணி , இயற்கை தகவல்தொடர்புகள் , ஹெப்ரான் நிறுவனம் ஆஃப் புற்றுநோயியல் , ஹெப்ரான் பல்கலைக்கழகம் மருத்துவமனை , மொழிபெயர்ப்பு ஆராய்ச்சி , ஹெப்ரான் நிறுவனம் , தேசிய மையம் ,

Immune Cells in Brain Predict Response to Immunotherapy

Immune Cells in Brain Predict Response to Immunotherapy
by Angela Mohan on
March 8, 2021 at 6:18 PM
Immune cells accessing cerebrospinal fluid recapitulate the characteristics of cells identified in brain metastasis, and could therefore constitute novel biomarkers of response to immune-based therapies, as per the study in
Nature Communications, led by Joan Seoane, Director of Preclinical and Translational Research co-program at VHIO and ICREA Professor.
Immune checkpoint inhibitors including anti-PD1, anti-PD-L1, and anti-CTLA4, have shown significant clinical benefits in patients with progressive or metastatic solid tumors, including some brain metastasis.
Notably, these immune-based therapies have improved outcomes for some of those suffering from lung cancer and melanoma. Together, these tumor types (represent between 30-40% of all cancers), along with breast cancer, are three common malignancies that lead to brain metastases. ....

Comunidad Autonoma De Cataluna , Joan Seoane , Holger Heyn , Single Cell Genomics Team , Nature Communications , National Centre For Genomic Analysis , Centre For Genomic Regulation , Hebron University Hospital , Translational Research , Neurosurgery Services , Corresponding Author , National Centre , Genomic Analysis Centre , Genomic Regulation , Cell Genomics Team , Intelligence Quotient , Pollen Allergylanguage Areas , Brain Metastasis , Immune Cells , Novel Biomarkers , காமுனிடட தன்னாட்சி டி கடலுள் , ஜோன் சேஓநெ , ஒற்றை செல் மரபியல் அணி , இயற்கை தகவல்தொடர்புகள் , ஹெப்ரான் பல்கலைக்கழகம் மருத்துவமனை , மொழிபெயர்ப்பு ஆராய்ச்சி ,

Immune cells in cerebrospinal fluid predict response to immunotherapy

Immune cells in cerebrospinal fluid predict response to immunotherapy
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

Israel General , Comunidad Autonoma De Cataluna , Ester Bonfill Teixidor , Garazi Serna , Sociedad Espa , Sara Ruiz , Josep Gonzalez , Laura Escudero , Raffaella Iurlaro , Francisco Mart , Amanda Wren , Estela Pineda , Esteban Cordero , Catia Moutinho , Juan Sahuquillo , Marta Cicuendez , Domenica Marchese , Paolo Nuciforo , Joan Seoane , Alexandra Arias , Leire Pedrosa , Juanl Trincado , Le Rhun , Josep Tabernero , Carlota Rubio Perez , Ester Planas ,

Immune cells in cerebrospinal fluid: predictors of response to immunotherapy against brain metastasis

Immune cells in cerebrospinal fluid: predictors of response to immunotherapy against brain metastasis
vhio.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from vhio.net Daily Mail and Mail on Sunday newspapers.

Comunidad Autonoma De Cataluna , Ester Bonfill Teixidor , Garazi Serna , Sociedad Espa , Josep Gonzalez , Sara Ruiz , Laura Escudero , Raffaella Iurlaro , Francisco Mart , Estela Pineda , Esteban Cordero , Catia Moutinho , Juan Sahuquillo , Marta Cicuendez , Domenica Marchese , Paolo Nuciforo , Alexandra Arias , Joan Seoane , Leire Pedrosa , Juanl Trincado , Le Rhun , Carlota Rubio Perez , Josep Tabernero , Ester Planas , Holger Heyn , Nature Communications ,

Immune cells in cerebrospinal fluid could be novel biomarkers to immune-based therapies

Immune cells in cerebrospinal fluid could be novel biomarkers to immune-based therapies
news-medical.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from news-medical.net Daily Mail and Mail on Sunday newspapers.

Israel General , Comunidad Autonoma De Cataluna , Joan Seoane , Holger Heyn , Emily Henderson , Nature Communications , National Centre For Genomic Analysis , Centre For Genomic Regulation , Hebron University Hospital , Translational Research Co , Neurosurgery Services , Single Cell Genomics Team , Hebron Institute Of Oncology , Study Co , Translational Research , Corresponding Author , Study Co Corresponding Author , Translational Research Co Program , Hebron Institute , National Centre , Genomic Analysis Centre , Genomic Regulation , Cell Genomics Team , இஸ்ரேல் ஜநரல் , காமுனிடட தன்னாட்சி டி கடலுள் , ஜோன் சேஓநெ ,