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Researchers demonstrate in a proof-of-concept study that a phage-based inhalation delivery system for vaccines generates potent antibody responses in mice and non-human primates, without causing lung damage. The findings suggest that a safe and effective lung delivery system could one day be used for vaccines and therapeutics against respiratory diseases. The results appear December 10 in the journal
Med. This translational strategy potentially enables more effective delivery of therapeutics or vaccines while reducing the chance of toxic side effects, says co-senior study author Wadih Arap of Rutgers Cancer Institute of New Jersey. In ongoing research, we hope that this work will play a crucial role in the development of targeted vaccines and treatments to block the spread of respiratory infectious diseases, possibly for the current COVID-19 pandemic, especially in the setting of underserved populations.