in terms of vaccine escape, this variant like if you remember the b. 13 p51 out of south africa lt year? it has similar mutations. if you get a high level there for you with some cross protections. they should have some level of protection. we don t know that for certain. our scientists over the weekend and this week at our texas children s center for vaccine development as well as almost certainly moderna, pfizer, j&j are looking at the antibody responses to each of our vaccines and see if they effecttismly neutralize of the omicron virus. i think we can know that pretty soon. it may not be eye couple of weeks. i think by the end of this week