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New computer tools can reconstruct 3D brain from biobank photos

Behind the paper: neuronal activity can drive cerebrospinal fluid flow in the human brain

In this 'behind the paper' post, Stephanie Williams discusses how the new equipment, techniques and methods developed in her lab helped them find out what drives cerebrospinal fluid flow in the human brain.

Noninvasive theta-burst stimulation of the human striatum enhances striatal activity and motor skill learning

The stimulation of deep brain structures has thus far only been possible with invasive methods. Transcranial electrical temporal interference stimulation (tTIS) is a novel, noninvasive technology that might overcome this limitation. The initial proof-of-concept was obtained through modeling, physics experiments and rodent models. Here we show successful noninvasive neuromodulation of the striatum via tTIS in humans using computational modeling, functional magnetic resonance imaging studies and behavioral evaluations. Theta-burst patterned striatal tTIS increased activity in the striatum and associated motor network. Furthermore, striatal tTIS enhanced motor performance, especially in healthy older participants as they have lower natural learning skills than younger subjects. These findings place tTIS as an exciting new method to target deep brain structures in humans noninvasively, thus enhancing our understanding of their functional role. Moreover, our results lay the groundwork for i

Researchers develop innovative technique for distinguishing tumor from normal tissue

Fluorescence lifetime imaging shows promise for improved tumor detection

Removing a patient's tumor while sparing healthy tissue requires exquisite precision, but often surgeons must rely on their eyes and hands to determine where to cut.