Levetiracetam and clobazam can cause a rare but serious drug reaction with eosinophilia and systemic symptoms that can be life threatening if not diagnosed and treated quickly, the FDA warns.
A retrospective observational study of three migraine cohorts in Canada suggests that acute medications, particularly opioids, are overused and that preventive medications are underused.
A large proportion of US adults prescribed Schedule II stimulants are simultaneously receiving other CNS agents, including benzodiazepines, opioids, and antidepressants.