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Diabète de type 2 : le rôle d'une protéine montré du doigt
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Alexey-pshezhetskyThey-wantஅவர்கள்-வேண்டும்Researchers identify a new mechanism underlying atherosclerosis
Glycomics researchers at the University of Alberta and CHU Sainte-Justine have reported a discovery that could lead to new treatments for cardiovascular disease.
The researchers identified a new mechanism responsible for the buildup of plaque on artery walls, a process known as atherosclerosis. This plaque, made up of fats, cholesterol and other substances, can restrict blood flow and is a major factor in cardiovascular disease.
We identified a new mechanism underlying atherosclerosis. We also demonstrated that this can be addressed pharmacologically. Using inhibitors developed in our lab, we found that this could be a new strategy for therapeutics in cardiovascular disease.
CairoAl-qahirahEgyptCanadaCanadiansCanadianTianlin-guoRadhika-chakrabertyWarren-wakarchukAlexey-pshezhetskyEmily-hendersonDepartment-of-chemistryA new combination therapy for treating rare, fatal Sanfilippo syndrome in children
A study aiming to develop a new therapeutic technique could bring a revolution in our approach to treating rare, fatal Sanfilippo syndrome, a disorder that affects children as young as 2 years old and leads to childhood dementia and premature death.
We are using a combination of gene therapy, stem cells and small molecules to restore metabolic defects in the patient s brain cells. First results in the mouse models of the disease are very encouraging.
Dr. Alexey Pshezhetsky, Professor at CHU Ste-Justine and Lead GlycoNet Investigator
Sanfilippo syndrome belongs to a group of rare diseases known as lysosomal storage disorders.
Alexey-pshezhetskyEmily-hendersonGlyconet-investigatorAshkenazi-jewishFrench-canadiansBloodBrainChildrenDementiaEnzymeGene