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Background: Recent data suggest an increased risk of congenital anomalies with prenatal exposure to opioid analgesics. We sought to further quantify the risk of anomalies after opioid analgesic exposure during the first trimester in a population-based cohort study.
Methods: Using administrative health data from Ontario, we followed 599 579 gestational parent–infant pairs from singleton pregnancies without opioid use disorder. We identified opioid analgesics dispensed in the first trimester and congenital anomalies diagnosed during the first year of life. We estimated propensity score–adjusted risk ratios (RRs) between first trimester exposure (any opioid analgesic and specific agents) and congenital anomalies (any anomaly, organ system anomalies, major or minor anomalies and specific anomalies).
Results: The prevalence of congenital anomalies was 2.8% in exposed infants and 2.0% in unexposed infants. Relative to unexposed infants, we observed elevated risks among thos ....
Stay in the loop Sign up for our free email newsletter. Unsubscribe anytime or contact us for details. Ontario Finance Minister (and apparent social media wizard?) Rod Phillips has returned home to Canada from the luxurious Caribbean island of St. Barts after more than two weeks of putting on sweaters for Zoom calls and otherwise trying to fool his constituents into thinking he d never left Ajax. Phillips did, as we all now know, leave Ontario for a tropical vacation with his wife on Dec. 13, despite the federal government s warnings against all non-essential travel and his own government s repeated pleas for people to stay home amid the pandemic. ....