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Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic
β cells. Individuals with type 1 diabetes are reliant on insulin for survival. Despite
enhanced knowledge related to the pathophysiology of the disease, including interactions
between genetic, immune, and environmental contributions, and major strides in treatment
and management, disease burden remains high. Studies aimed at blocking the immune
attack on β cells in people at risk or individuals with very early onset type 1 diabetes
show promise in preserving endogenous insulin production.
VestergaardSyddanmarkDenmarkLampeterCeredigionUnited-kingdomHerrathNordrhein-westfalenGermanyWasserfallPathirajaCentralThe COVID-19 pandemic has disproportionately affected certain groups, such as older
people (ie, >65 years), minority ethnic populations, and people with specific chronic
conditions including diabetes, cardiovascular disease, kidney disease, and some respiratory
diseases. There is now evidence of not only direct but also indirect adverse effects
of COVID-19 in people with diabetes. Recurrent lockdowns and public health measures
throughout the pandemic have restricted access to routine diabetes care, limiting
new diagnoses, and affecting self-management, routine follow-ups, and access to medications,
as well as affecting lifestyle behaviours and emotional wellbeing globally.
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