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#VisualAbstract: Overall Survival Improved with Adjuvant Pembrolizumab in Renal-Cell Carcinoma

1. The overall survival at 48 months was 91.2% in the pembrolizumab group vs 86.0% in the placebo group, with an HR 0.62 (significant). 2. Adverse events grade 3 or higher occurred in 18.6% of the pembrolizumab group vs 1.2% in the placebo group. Evidence Rating Level: 1 (Excellent) Study Rundown: Adjuvant therapy for localized ....

Rating Level , Adjuvant Pembrolizumab , Adjuvant Immunotherapy , Renal Cell Carcinoma ,

Overall Survival Improved with Adjuvant Pembrolizumab in Renal-Cell Carcinoma

1. The overall survival at 48 months was 91.2% in the pembrolizumab group vs 86.0% in the placebo group, with an HR 0.62 (significant). 2. Adverse events grade 3 or higher occurred in 18.6% of the pembrolizumab group vs 1.2% in the placebo group. Evidence Rating Level: 1 (Excellent) Study Rundown: Adjuvant therapy for localized ....

Rating Level , Adjuvant Pembrolizumab , Adjuvant Immunotherapy , Renal Cell Carcinoma , Chronic Disease ,

Dr Apolo on Adjuvant Pembrolizumab in Muscle-Invasive Urothelial Carcinoma

Andrea B. Apolo, MD, discusses the AMBASSADOR Alliance A031501 trial of adjuvant pembrolizumab in locally advanced/muscle-invasive urothelial carcinoma. ....

National Institutes Of Health , Genitourinary Malignancies Branch , Bladder Cancer Section , Bladder Cancer , Genitourinary Tumors Multidisciplinary Clinic , National Institutes , Andreab Apolo , Ambassador Alliance A031501 Trial , Adjuvant Pembrolizumab , Locally Advanced Muscle Invasive Urothelial Carcinoma ,

Adjuvant Pembrolizumab Improves DFS, But Not OS, in Locally Advanced/Muscle-Invasive Urothelial Carcinoma

Adjuvant pembrolizumab generated a disease-free survival benefit vs observation in patients with muscle-invasive and locally advanced urothelial carcinoma. ....

United States , National Institutes Of Health , Bristol Myers Squibb , Collaborators Group , Drug Administration , National Institutes , African American , Alaskan Native , Bladder Cancer , Meta Analysis Collaborators , Adjuvant Pembrolizumab , Patients With Muscle Invasive And Locally Advanced Urothelial Carcinoma , Ambassador Alliance A031501 Trial , Andreab Apolo ,

Adjuvant Pembrolizumab Improves OS in Select Patients With RCC After Nephrectomy

Adjuvant treatment with pembrolizumab significantly improved overall survival vs placebo in patients with renal cell carcinoma at intermediate-high or high risk of recurrence after nephrectomy, or after nephrectomy and resection of metastatic lesions, meeting a key secondary end point of the phase 3 KEYNOTE-564 trial. ....

Merck Research Laboratories , Cancers Symposium , Adjuvant Pembrolizumab , Renal Cell Carcinoma , Genitourinary Cancer , Keynote 564 Trial , Asco Gu , 2023 Genitourinary Cancers Symposium , Fda Approval ,