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E-Mail Many patients with multiple myeloma, a type of blood cancer, eventually develop resistance to one treatment after another. That s in part because cancer stem cells drive the disease cells that continually self-renew. If a therapy can t completely destroy these malignant stem cells, the cancer is likely to keep coming back. Researchers at University of California San Diego School of Medicine and Ionis Pharmaceuticals are taking a new, targeted approach to myeloma treatment silencing IRF4, a gene that allows myeloma stem cells and tumor cells to proliferate and survive. Past studies have shown that high IRF4 levels are associated with lower overall survival rates for patients with the disease. ....
E-Mail IMAGE: Biomedical engineers have developed a technique to observe wound healing in real time, discovering a central role for cells known as fibroblasts. The work is the first demonstration of a. view more Credit: Jeroen Eyckmans, Juliann B. Tefft WASHINGTON, January 19, 2021 Biomedical engineers developed a technique to observe wound healing in real time, discovering a central role for cells known as fibroblasts. The work, reported in APL Bioengineering, by AIP Publishing, is the first demonstration of a wound closure model within human vascularized tissue in a petri dish. Prior investigations of wound healing have used animal models, but healing in humans does not occur the same way. One difference is that wounds in mice and rats, for example, can heal without granulation tissue, a type of tissue critical to the healing of human wounds. ....
In a study in mice and human cells, Johns Hopkins Medicine researchers say that they have developed a tiny, yet effective method for preventing premature birth. The vaginally delivered treatment contains nanosized (billionth of a meter) particles of drugs that easily penetrate the vaginal wall to reach the uterine muscles and prevent them from contracting. If proven effective in humans, the treatment could be one of the only clinical options available to prevent preterm labor. The FDA has recommended removing Makena (17-hydroxyprogesterone caproate), the only approved medicine for this purpose, from the market. The study was published Jan. 13, 2020, in the journal ....
Study: Fibroblast hormone promotes movement of hematopoietic stem cells Discovery expected to contribute towards more effective methods of harvesting stem cells from bone marrow donors. A Kobe University research group including graduate student ISHII Shinichi and Associate Professor KATAYAMA Yoshio (both of the Department of Hematology, Graduate School of Medicine) have discovered that fibroblast growth factor-23 (FGF23) produced by erythroblasts (cells that are the precursors of red blood cells) promotes the movement (mobilization) of hematopoietic stem cells into the peripheral blood. Up until now, FGF23 has been known for the role it plays in the kidneys as a hormone that regulates phosphate concentrations throughout the body. ....
Crizotinib is the first biomarker-driven therapy for relapsed or refractory anaplastic large cell lymphoma in children and young adults.<br /> ....