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Designer DNA therapeutic wipes out cancer stem cells, treats multiple myeloma in mice


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Many patients with multiple myeloma, a type of blood cancer, eventually develop resistance to one treatment after another. That s in part because cancer stem cells drive the disease cells that continually self-renew. If a therapy can t completely destroy these malignant stem cells, the cancer is likely to keep coming back.
Researchers at University of California San Diego School of Medicine and Ionis Pharmaceuticals are taking a new, targeted approach to myeloma treatment silencing IRF4, a gene that allows myeloma stem cells and tumor cells to proliferate and survive. Past studies have shown that high IRF4 levels are associated with lower overall survival rates for patients with the disease. ....

San Diego , United States , University Of California San Diego , Ashnia Vora , Caitlin Costello , A Robert Macleod , Tianyuan Zhou , Catriona Jamieson , Elisa Lazzari , Phoebek Mondala , Xiaolin Luo , Youngsoo Kim , Translational Research Institute , National Cancer Institute , Drug Administration , Division Of Regenerative Medicine , Oncology At Ionis Pharmaceuticals , Sanford Stem Cell Clinical Center , Cancer Research , Uc San Diego Health , Ionis Pharmaceuticals , Moores Cancer Center , Uc San Diego School Of Medicine , California San Diego School , Cell Stem , Leslie Crews ,

New insights into wound healing process


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IMAGE: Biomedical engineers have developed a technique to observe wound healing in real time, discovering a central role for cells known as fibroblasts. The work is the first demonstration of a.
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Credit: Jeroen Eyckmans, Juliann B. Tefft
WASHINGTON, January 19, 2021 Biomedical engineers developed a technique to observe wound healing in real time, discovering a central role for cells known as fibroblasts. The work, reported in
APL Bioengineering, by AIP Publishing, is the first demonstration of a wound closure model within human vascularized tissue in a petri dish.
Prior investigations of wound healing have used animal models, but healing in humans does not occur the same way. One difference is that wounds in mice and rats, for example, can heal without granulation tissue, a type of tissue critical to the healing of human wounds. ....

District Of Columbia , United States , Juliann Tefft , Christophers Chen , Juliannb Tefft , Jeroen Eyckmans , Biomechanics Biophysics , Chemistry Physics Materials Sciences , Medicine Health , மாவட்டம் ஆஃப் கொலம்பியா , ஒன்றுபட்டது மாநிலங்களில் , கிறிஸ்டோபர்கள் சென் , பயோமெக்கானிக்ஸ் உயிர் இயற்பியல் , வேதியியல் இயற்பியல் பொருட்கள் அறிவியல் , மருந்து ஆரோக்கியம் ,

Research news tip sheet: Story ideas from Johns Hopkins Medicine


In a study in mice and human cells, Johns Hopkins Medicine researchers say that they have developed a tiny, yet effective method for preventing premature birth. The vaginally delivered treatment contains nanosized (billionth of a meter) particles of drugs that easily penetrate the vaginal wall to reach the uterine muscles and prevent them from contracting. If proven effective in humans, the treatment could be one of the only clinical options available to prevent preterm labor. The FDA has recommended removing Makena (17-hydroxyprogesterone caproate), the only approved medicine for this purpose, from the market.
The study was published Jan. 13, 2020, in the journal ....

United States , Anna Beavis , Elliott Haut , Michaele Newman , Anne Rositch , Marisol Martinez , Stephanie Wethington , Johns Hopkins , Rachel Butch , Us Centers For Disease , Johns Hopkins University School Of Medicine , Division Of Gynecologic Oncology , Hopkins Community Connection , Johns Hopkins Center , Johns Hopkins Bloomberg School Of Public Health , Canadian Medical Association Journal , American Cancer Society , Johns Hopkins Medicine , Science Translational , Laura Ensign , Johns Hopkins University School , Disease Control , Brandyn Lau , Johns Hopkins Bloomberg School , Public Health , Addressing Racial Disparities ,

Study: Fibroblast hormone promotes movement of hematopoietic stem cells


Study: Fibroblast hormone promotes movement of hematopoietic stem cells
Discovery expected to contribute towards more effective methods of harvesting stem cells from bone marrow donors.
A Kobe University research group including graduate student ISHII Shinichi and Associate Professor KATAYAMA Yoshio (both of the Department of Hematology, Graduate School of Medicine) have discovered that fibroblast growth factor-23 (FGF23) produced by erythroblasts (cells that are the precursors of red blood cells) promotes the movement (mobilization) of hematopoietic stem cells into the peripheral blood.
Up until now, FGF23 has been known for the role it plays in the kidneys as a hormone that regulates phosphate concentrations throughout the body. ....

United States , Emily Henderson , Ya Kobe University , School Of Medicine , Department Of Hematology , Kobe University , Associate Professor , Graduate School , Bone Marrow , Bone Marrow Transplant , Growth Factor , Red Blood Cells , Stem Cells , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , பள்ளி ஆஃப் மருந்து , துறை ஆஃப் ஹீமாட்டாலஜி , கோபி பல்கலைக்கழகம் , இணை ப்ரொஃபெஸர் , பட்டதாரி பள்ளி , எலும்பு மஜ்ஜை , எலும்பு மஜ்ஜை மாற்று , வளர்ச்சி காரணி , சிவப்பு இரத்தம் செல்கள் , தண்டு செல்கள் ,