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Dana-Farber to offer first CAR T-cell therapy for indolent follicular lymphoma following FDA approval

Axi-cel shown to produce long-term remissions in patients with slow-growing form of the disease The Food and Drug Administration (FDA) approval of the. ....

Caron Jacobson , Dana Farber Brigham , Women Cancer Center , Drug Administration , Cancer Center , Dana Farber Cancer Institute , Clinical Trials , Blood Cancer , கரோன் ஜாகோப்சன் , டானா ஃபார்‌பர் ப்ரிகாம் , பெண்கள் புற்றுநோய் மையம் , புற்றுநோய் மையம் , டானா ஃபார்‌பர் புற்றுநோய் நிறுவனம் , மருத்துவ சோதனைகள் , இரத்தம் புற்றுநோய் ,

When the doctor is the patient

When the doctor is the patient
A kidney transplant and a cancer diagnosis helped shape the career of infection-control expert Steve Pergam
March 23, 2015
•
By Mary Engel
/ Fred Hutch News Service
As director of infection control at Seattle Cancer Care Alliance and an infectious disease researcher at Fred Hutchinson Cancer Research Center, Dr. Steve Pergam works to protect a subset of people who are particularly vulnerable to infectious diseases: cancer patients. Here he is shown with graduate research assistant Arianna Miles-Jay.
Photo by Bo Jungmayer / Fred Hutch News Service
As a first-year medical student at University of Nebraska Medical Center, Dr. Steve Pergam volunteered for a vaccine campaign in Nicaragua, bringing basic childhood immunizations to squatters living in cardboard shacks. When he returned to Nicaragua the following spring to deliver a second round of immunizations, he fo ....

New Mexico , United States , University Of New Mexico , Fred Hutch , Larry Corey , University Of New Mexico School Medicine , Infectious Disease Division , University Of Washington , Clinical Research , New Mexico School , Fred Hutch Vaccine , Infectious Disease , Steven Pergam , Infectious Diseases , Seattle Cancer Care Alliance , Vaccine And Infectious Disease , Infection Control Program , Fred Hutchinson Cancer Research Center , Targeting Cancers Caused By Infectious Diseases , புதியது மெக்ஸிகோ , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் புதியது மெக்ஸிகோ , ஃப்ரெட் ஹட்ச் , லாரி கோரி , பல்கலைக்கழகம் ஆஃப் புதியது மெக்ஸிகோ பள்ளி மருந்து , தொற்று நோய் பிரிவு ,

Experimental safety switch reduces severity of CAR-T immunotherapy-related side effects

Experimental safety switch reduces severity of CAR-T immunotherapy-related side effects
UNC Lineberger Comprehensive Cancer Center researchers have successfully used an experimental safety switch, incorporated as part of a chimeric antigen receptor T-cell (CAR-T) therapy, a type of immunotherapy, to reduce the severity of treatment side effects that sometimes occur. This advance was seen in a patient enrolled in a clinical trial using CAR-T to treat refractory acute B-cell leukemia. It demonstrates a proof-of-principle for possible expanded use of CAR-T immunotherapy paired with the safety switch.
The researchers published their findings in the journal
Blood as an ahead-of-print publication.
With CAR-T therapy, T-cells from a patient s immune system are modified in a manufacturing facility to express part of an antibody that can bind to a surface protein on cancer cells. The modified T-cells, after being infused back into the patient, seek out and attack cancer ce ....

Matthew Foster , Jonathan Serody , Emily Henderson , Lineberger Cellular Immunotherapy Program , Cellular Immunotherapy Program , Lineberger Cellular Therapy Program , School Of Medicine , Bellicum Pharmaceuticals , Lineberger Comprehensive Cancer Center , Comprehensive Cancer Center , Gianpietro Dotti , Cellular Therapy , Acute Lymphoblastic Leukemia , Chimeric Antigen Receptor , Clinical Trial , Immune System , T Cell , மேத்யூ வளர்ப்பு , எமிலி ஹென்டர்சன் , லிநேபேர்கேற் செல்லுலார் நோயெதிர்ப்பு சிகிச்சை ப்ரோக்ர்யாம் , செல்லுலார் நோயெதிர்ப்பு சிகிச்சை ப்ரோக்ர்யாம் , லிநேபேர்கேற் செல்லுலார் சிகிச்சை ப்ரோக்ர்யாம் , பள்ளி ஆஃப் மருந்து , லிநேபேர்கேற் விரிவான புற்றுநோய் மையம் , விரிவான புற்றுநோய் மையம் , செல்லுலார் சிகிச்சை ,

Innovative cancer treatment effective in combating fungal infection in vitro and in mice

Innovative cancer treatment effective in combating fungal infection in vitro and in mice
An innovative cell-based treatment for cancer has been found promising for the control of infections caused by fungi. A study published in the journal
Cytotherapy reports that the use of CAR (chimeric antigen receptor) T-cells programmed to recognize
Cryptococcus spp. fungi was effective in combating infection in vitro and in mice.
C. gattii and
C. neoformans are present in soil with dead organic matter and places contaminated by the droppings of pigeons and other birds. They cause systemic mycoses in the human organism. They can infect the lungs and central nervous system, causing meningitis or meningoencephalitis. The symptoms vary according to the site of the infection, which can be fatal. Transmission occurs by inhalation of the fungi. ....

United States , Bioagents Biocel , Paulo Ribeir , Emily Henderson , Department Of Cellular , Preto Medical School , Dissemination Center , Us Centers For Disease , Drug Administration , Md Anderson Cancer Center , Disease Control , Thiago Aparecido , Molecular Biology , Pathogenic Bioagents , Brazilian Researcher , Young Investigator , Cancer Center , Cell Based Therapy , Cancer Treatment , Cell Wall , Central Nervous System , Chimeric Antigen Receptor , Cryptococcal Meningitis , Immune Response , In Vitro , Nervous System ,

Outlook on the Severe Toxicities in Lymphoma Global Industry to 2030 - Insight, Epidemiology and Market Forecast

Press release content from Business Wire. The AP news staff was not involved in its creation. ....

United States , United Kingdom , Laura Wood , E St Office Hours Call , Office Hours Call , Market Forecast , Severe Toxicities , Senior Press , Free Call , Hours Call , Business Wire , Western Europe , Diseases And Conditions , Medical Research , Diagnosis And Treatment , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , லாரா மரம் , ஏ ஸ்டம்ப் அலுவலகம் மணி அழைப்பு , அலுவலகம் மணி அழைப்பு , சந்தை முன்னறிவிப்பு , மூத்தவர் ப்ரெஸ் , இலவசம் அழைப்பு , மணி அழைப்பு , வணிக கம்பி , மேற்கு யூரோப் ,