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Bispecific antibodies targeting mutant RAS neoantigens

Diabodies see the unseeable
RAS oncogene mutations are common in various cancers, controlling their growth and survival. Targeting mutant RAS proteins with antibodies has been unsuccessful due to low surface expression, even when targeting mutant RAS peptides presented via HLA on the surface of cancer cells. Douglass
et al. used phage display to generate single-chain variable fragments (scFvs) specific for mutant RAS peptide-HLA complexes. The authors tested various bispecific, T cell–engaging antibody formulations, finding that single-chain diabodies (scDbs) combining the aforementioned scFv with an anti-CD3 scFv were able to induce T cell activation and subsequent killing of tumor cells expressing mutant RAS peptide-HLA complexes. This scDb approach opens the door for antibody-based therapies against mutant neoantigens expressed at very low levels on the surface of cancer cells. ....

Rock Springs , United States , Astra Zeneca Medimmune Amplimmune , Ultramer Oligos , Bristol Myers Squibb , Johns Hopkins University , Commonwealth Fund , Bloomberg Kimmel Institute For Cancer Immunotherapy , National Institute Of Arthritis , Dk Ludwig Fund For Cancer Research , Comics Inc , Assembly Cloning Kit New England Biolabs , Tetramer Production Lab , Fred Hutchinson Immune Monitoring Lab , Johns Hopkins University Animal Care , Molecular Sciences , Ge Healthcare , Dracen Pharmaceuticals , Becton Dickinson , Dynavax Technologies Corporation , Lustgarten Foundation For Pancreatic Cancer Research , Drug Administration , Johns Hopkins University School Of Medicine , Axiomx Inc , Biomed Valley Discoveries Inc , Mark Foundation For Cancer Research ,

Hospitalizations among adults with chronic kidney disease in the United States: A cohort study

Hospitalizations among adults with chronic kidney disease in the United States: A cohort study
Sarah J. Schrauben ,
Affiliations
Renal, Electrolyte-Hypertension Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America,
Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America,
Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Roles
Formal analysis,
Methodology,
Writing – review & editing
Affiliation
Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America ....

United States , Eteläuomen Läi , Wayne State University , Vallabho Shah , Mahboob Rahman , Markl Unruh , Medae Pavkov , Lawrencej Appel , Raymondr Townsend , Pandurangas Rao , Robertg Nelson , Johns Hopkins University , National Institute Of Diabetes , International Classification Of Diseases , University Of Maryland , Michigan Institute For Clinical , Tulane Human Research Protection Office , Tulane University , Perelman School Of Medicine , Translational Research In Cardiometabolic Diseases , University Of Michigan , National Inpatient Sample , University Kidney Research Organization , Cleveland Clinic Foundation Institutional Review Board , Health Research , University Of Illinois At Chicago ,