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Innovative strategy for early diagnosis of schizophrenia


Innovative strategy for early diagnosis of schizophrenia
An innovative strategy that analyzes a region of the genome offers the possibility of early diagnosis of schizophrenia, reports a team led by researchers at Baylor College of Medicine. The strategy applied a machine learning algorithm called SPLS-DA to analyze specific regions of the human genome called CoRSIVs, hoping to reveal epigenetic markers for the condition.
In DNA from blood samples, the team identified epigenetic markers, a profile of methyl chemical groups in the DNA, that differ between people diagnosed with schizophrenia and people without the disease and developed a model that would assess an individual s probability of having the condition. Testing the model on an independent dataset revealed that it can identify schizophrenia patients with 80% accuracy. The study appears in the journal ....

Roberta Waterland , Chathuraj Gunasekara , Emily Henderson , Children Nutrition Research Center At Baylor , Baylor College Of Medicine , Baylor College , Nutrition Research Center , ரோபர்ட்டா நீர்நிலம் , எமிலி ஹென்டர்சன் , குழந்தைகள் ஊட்டச்சத்து ஆராய்ச்சி மையம் இல் பேலர் , பேலர் கல்லூரி ஆஃப் மருந்து , பேலர் கல்லூரி , ஊட்டச்சத்து ஆராய்ச்சி மையம் ,