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Credit: Dr Lori Peacock Researchers at the University of Bristol have discovered how microbes responsible for human African sleeping sickness produce sex cells. In these single-celled parasites, known as trypanosomes, each reproductive cell splits off in turn from the parental germline cell, which is responsible for passing on genes. Conventional germline cells divide twice to produce all four sex cells - or gametes - simultaneously. In humans four sperms are produced from a single germline cell. So, these strange parasite cells are doing their own thing rather than sticking to the biology rulebook. Trypanosome cell biology has already revealed several curious features. They have two unique intracellular structures - the kinetoplast, a network of circular DNA and the glycosome, a membrane-enclosed organelle that contains the glycolytic enzymes. They don t follow the central dogma that DNA is faithfully transcribed into RNA, but will go back and edit some of the RNA transcripts af

City ofUnited kingdomChris kayLori peacockWendy gibsonMark carringtonMick baileyChloe farrenUniversity of cambridgeUniversity of bristol school biological sciencesCommunications biologyBristol school of biological sciencesSchool of veterinary sciencesUniversity of bristolBiological sciencesVeterinary sciences