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Predicting drug absorption in miniatured human liver

Kyoto University
The Kazuo Takayama lab reports that PDMS-based liver-on-chip naturally absorb some drugs, which affects drug toxicity results.
Liver-on-a-chip are miniaturized devices that capture the physiological and mechanical properties of the liver. They are commonly used by researchers to study how the liver metabolizes different compounds and drugs. In a new study seen in ACS Biomaterials Science & Engineering, CiRA Junior Associate Professor Kazuo Takayama and colleagues report which drugs based on their physicochemical properties are most suitable when using liver-on-a-chip to study drug toxicity.
One of the most important tests for any drug approval is hepatotoxicity. In fact, the United States Food and Drug Administration claims it is the number one cause of safety-related drug withdrawal from the market. Thus, exhaustive testing is mandatory, as otherwise a company that has invested billions of dollars on a drug could see it all lost because of ....

United States , Emi Sano , Fumiyoshi Yamashita , Ryosuke Negoro , Hiroyuki Mizuguchi , Kazuo Takayama , Kaori Osugi , Ayaka Sakamoto , Natsumi Mimura , Kazuya Maeda , Sayaka Deguchi , Masahiro Tsuda , Hiroyuki Kusuhara , Ritsumeikan University , Laboratory Of Molecular Pharmacokinetics , Ps Cell Research , Department Of Clinical Application , Kyoto University , Department Of Drug Delivery Research , Drug Administration , School Of Pharmaceutical Sciences , Department Of Micro Engineering , Laboratory Of Biochemistry , College Of Pharmaceutical Sciences Department , Osaka University , Department Of Applied Pharmaceuticals ,

Are genetic differences the primary reason for susceptibility and severity of COVID-19?

Are genetic differences the primary reason for susceptibility and severity of COVID-19?
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Kazuo Takayama , Ps Cell Research , Kyoto University , காஸூவொ தக்காயமா , ப்ச் செல் ஆராய்ச்சி , கியோட்டோ பல்கலைக்கழகம் ,

New iPSC model for COVID-19 | SelectScience

New iPSC model for COVID-19 | SelectScience
selectscience.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from selectscience.net Daily Mail and Mail on Sunday newspapers.

Kazuo Takayama , Ps Cell Research , Kyoto University Japan , Product News , Kyoto University , காஸூவொ தக்காயமா , ப்ச் செல் ஆராய்ச்சி , கியோட்டோ பல்கலைக்கழகம் ஜப்பான் , ப்ராடக்ட் செய்தி , கியோட்டோ பல்கலைக்கழகம் ,

Stem cells show gender differences in COVID-19 risk

Kyoto University
Graphical abstract
The Kazuo Takayama lab shows how iPS cells can be used to study SARS-CoV-2 and COVID-19.
With more than 125 million people infected and nearly 3 million dead, the COVID-19 pandemic has disrupted the world in inconceivable ways. Adding to the challenge is that the patient condition varies widely, from the asymptomatic to respiratory failure and death. A new study by CiRA researchers shows how iPS cells can be used to study infection by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), revealing gender differences seen with the disease.
One of the devasting aspects of COVID-19 is its unpredictable nature. An unknown number of people infected are asymptomatic, and those that do show symptoms range widely, from mild to severe. ....

Emi Sano , Yukiko Muramoto , Ayaka Sakamoto , Takuya Yamamoto , Takeshi Noda , Kazuo Takayama , Sayaka Deguchi , Institute For Frontier Life , Institute For Advanced Study Of Human Biology , Ps Cells Team , Kyoto University , Japan Agency For Medical Research , Technology Agency , Laboratory Of Ultrastructural Virology , Junior Associate Professor Kazuo Takayama , Ultrastructural Virology , Frontier Life , Medical Sciences , Japan Science , Advanced Study , Human Biology , Advanced Intelligence Project , Japan Agency , Medical Research , Gender Differences , Medical Research ,