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Antibody is first of three tau drugs to be evaluated Clinical trial participant Taylor Hutton (left) meets with Randall J. Bateman, MD, director of the global DIAN-TU Alzheimer’s clinical trial in 2018. Hutton’s family has a history of early-onset Alzheimer’s disease. The DIAN-TU is launching three new arms to evaluate experimental Alzheimer’s drugs targeting the protein tau. (Photo: Matt Miller/School of Medicine) March 15, 2021 SHARE A worldwide clinical trial aimed at finding treatments for Alzheimer’s disease has expanded to include investigational drugs targeting a harmful form of the brain protein tau. The trial, known as the Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU) and led by Washington University School of Medicine in St. Louis, launched in 2012 as the first prevention trial for Alzheimer’s disease. Originally focused on amyloid-based therapies, it was funded by the National Institute on Aging (NIA) of the National Ins ....
FRED MILLER To put you in the proper frame of mind for this story, forget the current spell of warm, springlike weather and go back to mid-February, with four inches of snow on the ground and a thermometer that hadn’t moved above freezing in three weeks. On one of the coldest of those mornings Honey asked me, “Have you seen Flop today? I haven’t seen him all morning. I’m a little worried.” No, I had not seen Flop the Cat, and I could not remember whether he had come in the night before. Of our three young ex-gentlemen cats, Flop during the cold weather had transitioned from the least likely to the most likely to ask to go outside. And it is less of an “ask” than a sudden bolt past one’s feet when one of us opened the front door to bring in firewood. The other two cats, Fizz and Louie, would think they wanted to go outside until the cold air hit their faces. ....
Johnny Depp s Revenge: Actor Receives Positive Responses Ahead City of Lies Release Johnny Depp continuously garners the support he deserves by making a comeback on big screens soon with the release of City of Lies. This week, the official YouTube channel of IGN released the new trailer of City of Lies. The video finally came out years after it has been delayed due to the lawsuit involving Depp and the film s location manager. City of Lies is based on the book LAbyrinth by Randall Sullivan, a Pulitzer Prize-winning author. The film tells the story of an investigation into the murder of iconic rap artist, Christopher Wallace/The Notorious B.I.G. ....