Review University Of South Florida Metabolic Therapy Laboratory In hillsborough, florida, united-states | Medical In Hillsborough

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University Of South Florida Metabolic Therapy Laboratory

Hillsborough,

Florida,United-states - 33612

Detailed description is Our laboratory develops and tests nutritional and metabolic therapies including ketogenic diets and ketogenic agents for cancer, seizures and disorders.
Dr.
D'Agostino is an Assistant Professor at the University of South Florida College Of Medicine, Molecular Pharmacology & Physiology where he develops and tests metabolic therapies, including alternative energy substrates and ketogenic agents for neurological disorders, cancer and wound healing.
While studying the effects of gasses on the brains of Navy Seal divers, he developed an approach for metabolically starving cancer cells through diet and compressed oxygen, replacing chemotherapy, surgery, or radiation..
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http://www.youtube.com/watch?v=3fM9o72ykww.
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Our laboratory at USF Morsani College of Medicine is growing in space, personnel and research interests.
Our Department of Molecular Pharmacology and Physiology has a faculty base with a broad range of expertise and backgrounds.
The main focus of our laboratory is to further expand on the development and application of metabolic therapies for the treatment of seizure disorders, metabolic disorders, neurodegenerative diseases, wound healing and cancer.
We now have four full time PhD students, a laboratory manager, a postdoctoral fellow and several highly motivated undergraduate and pre-medical students working in the laboratory..
Each member has a primary project, but they all work as a Team to support the efforts of others by collecting data, discussing the results and presenting the information to the public.
Our laboratory is equipped with a variety of equipment to assess the efficacy of metabolic therapies on neurological function, motor function and metabolism, which are all linked to clinical assessment in patients.
Collaboration is a very important and necessary part of forming a team of expertise to optimize the use of resources for scientific discovery.
We maintain collaborations with a number of institutions including Boston College, Case Western University, The University of Texas Southwestern Medical Center and the University on Tampa to name a few..
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Recent publications.
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Brownlow, ML.Benner, L.D'Agostino, D.Gordon, MN.Morgan, D.
Ketogenic diet improves motor performance but not cognition in two mouse models of Alzheimer's pathology.
PloS one.
8(9) : e75713, 2013.
http://www.ncbi.nlm.nih.gov/pubmed/24069439.
Seyfried, TN.Flores, R.Poff, AM.D'Agostino, DP.
Cancer as a Metabolic Disease: Implications for Novel Therapeutics.
Carcinogenesis.
, 2013.
http://www.ncbi.nlm.nih.gov/pubmed/24343361.
D'Agostino, DP.Pilla, R.Held, HE.Landon, CS.Puchowicz, M.Brunengraber, H.Ari, C.Arnold, P.Dean, JB.
Therapeutic ketosis with ketone ester delays central nervous system oxygen toxicity seizures in rats.
American journal of physiology.
Regulatory, integrative and comparative physiology.
304(10) : R829-36, 2013.
http://www.ncbi.nlm.nih.gov/pubmed/23552496.
Poff, AM.Ari, C.Seyfried, TN.D'Agostino, DP.
The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer.
PloS one.
8(6) : e65522, 2013.
http://www.ncbi.nlm.nih.gov/pubmed/23755243.
D'Agostino, DP.McNally, HA.Dean, JB.
Development and testing of hyperbaric atomic force microscopy (AFM) and fluorescence microscopy for biological applications.
Journal of microscopy.
246(2) : 129-42, 2012.
http://www.ncbi.nlm.nih.gov/pubmed/22455392.
Paoli, A.Grimaldi, K.D'Agostino, D.Cenci, L.Moro, T.Bianco, A.Palma, A.
Ketogenic diet does not affect strength performance in elite artistic gymnasts.
Journal of the International Society of Sports Nutrition.
9(1) : 34, 2012.
http://www.ncbi.nlm.nih.gov/pubmed/22835211.
McNally H; D'Agostino DP Hyperbaric Atomic Force Microscopy System Performance and Applications Imaging and Microscopy.
13(1) : 41-43, 2011..
D'Agostino, DP.Olson, JE.Dean, JB.
Acute hyperoxia increases liid peroxidation and induces plasma membrane blebbing in human U87 glioblastoma cells.
Neuroscience.
159(3) : 1011-22, 2009.
http://www.ncbi.nlm.nih.gov/pubmed/19356685.
D'Agostino, DP.Colomb, DG.Dean, JB.
Effects of hyperbaric gases on membrane nanostructure and function in neurons.
Journal of applied physiology.
106(3) : 996-1003, 2009.
http://www.ncbi.nlm.nih.gov/pubmed/18818382.
D'Agostino, D.Mazza, E.Neubauer, JA.
Heme oxygenase is necessary for the excitatory response of cultured neonatal rat rostral ventrolateral medulla neurons to hypoxia.
American journal of physiology.
Regulatory, integrative and comparative physiology.
296(1) : R102-18, 2009.
http://www.ncbi.nlm.nih.gov/pubmed/18971354.
D'Agostino, DP.Putnam, RW.Dean, JB.
Superoxide (*O2- ) production in CA1 neurons of rat hippocampal slices exposed to graded levels of oxygen.
Journal of neurophysiology.
98(2) : 1030-41, 2007.
http://www.ncbi.nlm.nih.gov/pubmed/17553943.


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