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Cells create own detergent to clean up infections

By Bill Hathaway July 15, 2021 Share this with FacebookShare this with TwitterShare this with LinkedInShare this with EmailPrint this (Illustration by Michael S. Helfenbein) In recent years, scientists have discovered that non-immune system cells are surprisingly well armed to combat infection. Yale researchers have found a particularly powerful weapon in these cells’ arsenal a protein that acts like a detergent to wipe out invading pathogens much like the way that Ajax cleans dirty dishes or sanitizes a kitchen countertop. This intracellular cleanser, the researchers say, dissolves membranes of invading bacteria that have replicated in the cytosol, the watery interior of cells. Importantly, the detergent-like immune protein does not harm the membranes of organelles belonging to the host cell, they report July 16 in the journal Science.

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