Scientific American
Psilocybin Therapy May Work as Well as Common Antidepressant
For the first time, a randomized controlled trial shows the psychedelic offers potent, if short-term, relief in comparison with an SSRI
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Psilocybin, the active ingredient in “magic mushrooms,” may provide relief from depression symptoms that is equivalent to, or better than, an SSRI antidepressant. Credit: Getty Images
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The first randomized controlled trial to compare the illicit psychedelic psilocybin with a conventional selective serotonin reuptake inhibitor (SSRI) antidepressant found that the psychedelic improved symptoms of depression just as well on an established metric and had fewer side effects. The study was fairly small, however, and was not explicitly intended to show how well the drugs stacked up on other measures of well-being.
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