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 E-Mail IMAGE: Ludwig Memorial Sloan Kettering s investigators Taha Merghoub, Jedd Wolchok and assistant attending physician Andrew Chow. view more  Credit: Ludwig Cancer Research JUNE 10, 2021, NEW YORK - A Ludwig Cancer Research study adds to growing evidence that immune cells known as macrophages inhabiting the body cavities that house our vital organs can aid tumor growth by distracting the immune system s cancer-killing CD8+ T cells. Reported in the current issue of Cancer Cell and led by Ludwig investigators Taha Merghoub and Jedd Wolchok at Memorial Sloan Kettering (MSK) and Charles Rudin of MSK, the study shows that cavity-resident macrophages express high levels of Tim-4, a receptor for phosphatidylserine (PS), a molecule that they surprisingly found on the surface of highly activated, cytotoxic and proliferative CD8+ T-cells.

United statesCharles rudinTaha merghoubAndrew chowSloan ketteringDanielk ludwigUs national cancer instituteWeill cornell medical collegeA ludwig cancer researchLudwig cancer researchEmerald foundationLudwig centerLudwig collaborative laboratoryLudwig collaborative swim across america laboratoryParker institute for cancer immunotherapyUs department of defense