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IIT-M identifies alternative method for producing anti-cancer drug Camptothecin
IIT-M identifies alternative method for producing anti-cancer drug Camptothecin
25 February 2021 | News Developed a microbial fermentation process that can be an economically efficient and sustainable method of production to fulfil the market demand at large scale
IIT Madras (IIT-M) Researchers have now developed an alternative method of Camptothecin production to meet the demand and conserve the natural sources. To this effect, they developed a microbial fermentation process that can be an economically efficient and sustainable method of production to fulfil the market demand at large scale.
The research was led by Dr Smita Srivastava, Associate Professor, Department of Biotechnology, IIT Madras. This work was recently published in the reputed peer-reviewed international Journal of Scientific Reports (a Nature Research Publication).
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They have developed an economically-efficient method of production
Researchers at the Indian Institute of Technology-Madras have identified a sustainable, high-yielding alternative source for the anti-cancer drug camptothecin.
Camptothecin is an alkaloid isolated from ‘Camptotheca Acuminata’, a Chinese tree and ‘Nothapodytes Nimmoniana’, an Indian tree. It requires nearly 1,000 tonnes of plant material to extract one tonne of camptothecin. In the past decade, the population of N. Nimmoniana fell by 20%, according to the researchers.
The researchers have developed a microbial fermentation process that can be an economically-efficient method of production to fulfil the market demand.
Two drugs, topotecan and irinotecan, are produced using camptothecin.
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