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 E-Mail In African Americans, the genetic risk landscape for inflammatory bowel disease (IBD) is very different from that of people with European ancestry, according to results of the first whole-genome study of IBD in African Americans. The authors say that future clinical research on IBD needs to take ancestry into account. Findings of the multi-center study, which analyzed the whole genomes of more than 1,700 affected individuals with Crohn s disease and ulcerative colitis and more than 1,600 controls, were published on February 17 in the American Journal of Human Genetics. As part of their analysis, the researchers developed an algorithm that corrects for ancestry when calculating an IBD polygenic risk score. Polygenic risk scores are tools for calculating gene-based risk for a disease, which are used for IBD as well as other complex conditions such as coronary artery disease.

United statesNew jerseyLisaz greerDermot mcgovernHari somineniSubra kugathasanJohns hopkinsRutgers crohnsSteven brantWashington university at saint louisNational institute of diabetesColitis centerNational institute of allergyChildren centerEmory university school of medicineCraniofacial research