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DGAP-PVR: Epigenomics AG: Release according to Article 40, Section 1 of the WpHG [the German Securities Trading Act] with the objective of Europe-wide distribution

DGAP-PVR: Epigenomics AG: Release according to Article 40, Section 1 of the WpHG [the German Securities Trading Act] with the objective of Europe-wide distribution Acquisition/disposal of instruments X Other reason: Notification is triggered due to the application of the Custody Exemption available under Sect. 36 Para. 3 No. 2 WpHG 3. Details of person subject to the notification obligation Legal entity: Morgan Stanley 4. Names of shareholder(s) holding directly 3% or more voting rights, if different from 3. 5. Date on which threshold was crossed or reached: 18 May 2021 (total of 7.a.) (total of 7.b.1 + 7.b.2) New a. Voting rights attached to shares (Sec. 33, 34 WpHG) ISIN Type of instrument

DGAP-PVR: Deutsche Börse AG: Release according to Article 40, Section 1 of the WpHG [the German Securities Trading Act] with the objective of Europe-wide distribution

DGAP-PVR: Deutsche Börse AG: Release according to Article 40, Section 1 of the WpHG [the German Securities Trading Act] with the objective of Europe-wide distribution Acquisition/disposal of instruments X Other reason: Notification is triggered mainly due to an acquisition of shares with voting rights and additionally due to the non application of the Custody Exemption available under Sect. 36 Para. 3 No. 2 WpHG 3. Details of person subject to the notification obligation Legal entity: Morgan Stanley 4. Names of shareholder(s) holding directly 3% or more voting rights, if different from 3. 5. Date on which threshold was crossed or reached: 13 May 2021

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